Design of nutrigenetic portfolios targeting CETP and LPL variants in the prevention of dyslipidemias.

Abstract

Introduction: Nutrigenetics enables the identification of genetic factors that modulate individual responses to dietary components, supporting the development of personalized nutritional strategies for the prevention and management of chronic diseases. Among these factors, genetic variants in CETP and LPL have been linked to an increased susceptibility to dyslipidemias. Designing nutrigenetic portfolios—dietary recommendations tailored to a person’s genetic profile—offers a promising approach to optimize metabolic health. Results: Evidence shows that carriers of the C allele in LPL may experience reductions in triglyceride levels when following diets rich in monounsaturated fats. In contrast, CETP variants, particularly the T (B2) allele, display significant interactions with the intake of simple carbohydrates and monounsaturated fats, influencing HDL cholesterol and triglyceride concentrations. Based on these findings, specific nutrigenetic recommendations include reducing monounsaturated fat intake and limiting sucrose consumption in individuals carrying risk variants in CETP (T allele) and LPL (T allele). Conclusions: Integrating genetic information into dietary planning can substantially enhance the prevention and treatment of dyslipidemias and cardiovascular diseases, reinforcing the value of personalized nutrition in clinical practice.